The following example shows basic usage of an AudioContext to create a Biquad filter node. For a complete working example, check out our voice-change-o-matic demo (look at the source code too).
var audioCtx = new (window.AudioContext || window.webkitAudioContext)();
//set up the different audio nodes we will use for the app
var analyser = audioCtx.createAnalyser();
var distortion = audioCtx.createWaveShaper();
var gainNode = audioCtx.createGain();
var biquadFilter = audioCtx.createBiquadFilter();
var convolver = audioCtx.createConvolver();
// connect the nodes together
source = audioCtx.createMediaStreamSource(stream);
// Manipulate the Biquad filter
biquadFilter.type = "lowshelf";
biquadFilter.frequency.value = 1000;
biquadFilter.gain.value = 25;
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