make.py (and the pymake modules that support it) are an implementation of the make tool which are mostly compatible with makefiles written for GNU make. http://benjamin.smedbergs.us/pymake/
Follow the build instructions, except for the "Build and install" section. Switch to the root of the source directory, then run autoconf-2.13 && ./configure. Change to your objdir and run python -O path_to_srcdir/build/make.py to start the build. If you hadn't specified mk_add_options MOZ_MAKE_FLAGS in your mozconfig, you can simply append the flags to the aforementioned Python command, e.g. -j2 runs two make jobs in parallel. Using a -j value equal to the number of CPU cores visible to the OS is recommended.